Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3590221 | 0.79 | MCHR1 (0.56) | LMNA | |
| SCHEMBL4622305 | 0.77 | CCKBR (0.50) | CPB2FAAHCCKBR | |
| SCHEMBL2243798 | 0.77 | HDAC3 (0.46) | — | |
| SCHEMBL4365443 | 0.76 | CCKBR (0.49) | CPB2FAAHCCKBR | |
| SCHEMBL2247584 | 0.76 | MCHR1 (0.43) | ALDH1A1HPGDCCKBRKMT2AMEN1 | |
| SCHEMBL4623284 | 0.75 | FAAH (0.53) | NPC1RAB9AEPHX2FAAHCCKBR | |
| SCHEMBL2247325 | 0.74 | ADAMTS5 (0.61) | — | |
| SCHEMBL2252635 | 0.73 | KMT2A (0.47) | ALDH1A1HPGDCCKBRKMT2AMEN1 | |
| SCHEMBL4621773 | 0.73 | MCHR1 (0.36) | ALDH1A1KDM4ELMNAHPGDHTT | |
| SCHEMBL2246238 | 0.72 | MCHR1 (0.47) | ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | claimed |