Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5462542 | 0.88 | PPARG (0.37) | PPARGADAM17 | |
| SCHEMBL4560210 | 0.84 | SIRT1 (0.42) | ADAM17 | |
| SCHEMBL2256428 | 0.82 | HDAC1 (0.40) | PPARGADAM17 | |
| SCHEMBL404699 | 0.79 | PPARG (0.46) | HPGDPPARGALDH1A1 | |
| SCHEMBL1095462 | 0.78 | PPARG (0.43) | PPARGALDH1A1 | |
| SCHEMBL3758442 | 0.77 | LMNA (0.55) | HPGDSIGMAR1TMEM97ACKR3ALDH1A1 | |
| SCHEMBL1105494 | 0.77 | ANPEP (0.44) | PPARGALDH1A1 | |
| SCHEMBL1105490 | 0.76 | PPARG (0.41) | PPARGALDH1A1 | |
| SCHEMBL1109433 | 0.75 | HDAC1 (0.46) | PPARG | |
| SCHEMBL1109349 | 0.74 | CYP1A2 (0.47) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101640-B2 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110172174-A1 | Antibacterial agents | NOVARTIS VACCINES AND DIAGNOSTICS INC. | 2011-07-14 | — | — | US | disclosed |
| US-20090163496-A1 | ANTIBACTERIAL AGENTS | UNIVERSITY OF WASHINGTON (US) | 2009-06-25 | — | — | US | disclosed |
| US-20070244197-A1 | Antibacterial agents | UNIVERSITY OF WASHINGTON (US) | 2007-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244197-A1 | Antibacterial agents | MRPL21, SI, PGLS | HPGD 408/4885SIGMAR1 776/4885TMEM97 3828/4885 |
| US-20110172174-A1 | Antibacterial agents | MRPL21, SI, PGLS | HPGD 408/4885SIGMAR1 776/4885TMEM97 3828/4885 |
| US-20090163496-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, PGLS | HPGD 408/4885SIGMAR1 776/4885TMEM97 3828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.