Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 7/20 | 0.58 |
| ▸ | NCF1 | P14598 | 4/20 | 0.52 |
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | NOS1 | P29475 | 3/20 | 0.51 |
| ▸ | NOS3 | P29474 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | TEC | P42680 | 1/20 | 0.46 |
| ▸ | NCK1 | P16333 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2130719 | 0.84 | BACE1 (0.72) | BACE1NCF1NOS2PIK3CGPLAU | |
| SCHEMBL2133059 | 0.81 | NR4A2 (0.54) | BACE1NOS1NR4A2PIK3CGLMNA | |
| SCHEMBL30506415 | 0.81 | NR4A2 (0.54) | BACE1NOS1NR4A2PIK3CGLMNA | |
| SCHEMBL16735797 | 0.77 | NR4A2 (0.51) | BACE1NR4A2PIK3CGLMNACYP1A2 | |
| SCHEMBL7014346 | 0.76 | PLAU (0.71) | BACE1NCF1NOS2PLAULMNA | |
| SCHEMBL7608692 | 0.75 | NR4A2 (0.52) | BACE1NOS1NR4A2PIK3CGLMNA | |
| SCHEMBL11057520 | 0.74 | LMNA (0.75) | BACE1NR4A2PIK3CGPLAULMNA | |
| SCHEMBL23779362 | 0.73 | NR4A2 (0.50) | BACE1NOS1NR4A2PIK3CGLMNA | |
| SCHEMBL11973788 | 0.73 | BACE1 (0.57) | BACE1NCF1NOS2NOS1PLAU | |
| SCHEMBL23453134 | 0.73 | BACE1 (0.57) | BACE1NCF1NOS2NOS1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107266323-B | A kind of side chain and its synthetic method, and the method using side chain synthesis hydroxychloroquine sulfate | 宜宾莱特医药化工有限公司 | 2019-04-19 | — | — | CN | claimed |
| CN-107266323-A | A kind of side chain and its synthetic method, and using the method for side chain synthesis hydroxychloroquine sulfate | 宜宾莱特医药化工有限公司 | 2017-10-20 | — | — | CN | claimed |
| US-12479803-B2 | Antimalarial compounds | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2025-11-25 | — | — | US | disclosed |
| CN-114133377-B | Quinoline-1, 2, 4-triazine hybrid, preparation method and application thereof | 江苏海洋大学 | 2023-05-02 | — | — | CN | disclosed |
| WO-2022191092-A1 | QUINOLINE COMPOUND, HNMT INHIBITOR, AND AGENT FOR PREVENTING/TREATING ADHD, NARCOLEPSY, OR ALZHEIMER'S DISEASE | 国立大学法人東北大学 | 2022-09-15 | — | — | WO | disclosed |
| US-20220204452-A1 | ANTIMALARIAL COMPOUNDS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. | 2022-06-30 | — | — | US | disclosed |
| WO-2020206252-A1 | ANTIMALARIAL COMPOUNDS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-10-08 | — | — | WO | disclosed |
| CN-107266323-B | A kind of side chain and its synthetic method, and the method using side chain synthesis hydroxychloroquine sulfate | 宜宾莱特医药化工有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-107266323-B | A kind of side chain and its synthetic method, and the method using side chain synthesis hydroxychloroquine sulfate | 宜宾莱特医药化工有限公司 | 2019-04-19 | — | — | CN | disclosed |
| CN-108484497-A | A kind of synthetic method of 3- amino -7- chloroquinolines | 苏州康润医药有限公司 | 2018-09-04 | — | — | CN | disclosed |
| CN-107266323-A | A kind of side chain and its synthetic method, and using the method for side chain synthesis hydroxychloroquine sulfate | 宜宾莱特医药化工有限公司 | 2017-10-20 | — | — | CN | disclosed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | disclosed |
| US-4642308-A | ANTICONVULSANTS, ANXIOLYTIC AGENTS, ANTIEPILEPTIC AGENTS, HYPNOTICS, MUSCLE RELAXANTS | RHONE-POULENC SANTE (FR) | 1987-02-10 | — | — | US | disclosed |
| US-4327095-A | TRANQUICIZERS, ANTICONVULSANTS DECONTRACTURANTS AND HYPNOGENIC AGENTS | RHONE-POULENC INDUSTRIES (FR) | 1982-04-27 | — | — | US | disclosed |
| US-4279912-A | ANTIALLERGENS, BRONCHODILATORS | ROUSSEL UCLAF (FR) | 1981-07-21 | — | — | US | disclosed |
| US-4220646-A | TRANQUILIZERS, ANTICONVULSANTS, MUSCLE RELAXANTS, HYPNOTIC AGENTS | RHONE-POULENC INDUSTRIES (FR) | 1980-09-02 | — | — | US | disclosed |
| US-4124711-A | TRANQUILIZERS, ANTICONVULSANTS, DECONTRACTURANTS, HYPNOTIC AGENTS | RHONE-POULENC INDUSTRIES (FR) | 1978-11-07 | — | — | US | disclosed |
| US-4021554-A | 1,4-Oxathiino[2,3-c]pyrrole derivatives | RHONE-POULENC INDUSTRIES (FR) | 1977-05-03 | — | — | US | disclosed |
| US-3966931-A | TRANQUILIZERS, ANTICONVULSANTS, HYPNOSIS | RHONE-POULENC S.A. (FR) | 1976-06-29 | — | — | US | disclosed |
| US-3948917-A | TRANQUILIZERS, ANTICONVULSANTS, DECONTRACTURANTS, HYPNOSIS | RHONE-POULENC S.A. (FR) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12479803-B2 | Antimalarial compounds | H1-3, FPR3, NHERF1 | BACE1 3579/4885NCF1 38/4885NOS2 593/4885 |
| US-20220204452-A1 | ANTIMALARIAL COMPOUNDS | H1-3, FPR3, NHERF1 | BACE1 3579/4885NCF1 38/4885NOS2 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.