Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4095860 | 0.82 | CA2 (0.47) | KMT2AMEN1EPHX1CA2NPC1 | |
| SCHEMBL16684123 | 0.82 | CA2 (0.49) | KMT2AMEN1EPHX1CA2NPC1 | |
| SCHEMBL10437254 | 0.81 | CA2 (0.46) | KMT2AMEN1EPHX1CA2NPC1 | |
| SCHEMBL6100381 | 0.81 | CA2 (0.46) | KMT2AMEN1EPHX1CA2NPC1 | |
| SCHEMBL18444555 | 0.78 | CA2 (0.54) | KMT2AMEN1EPHX1CA2NPC1 | |
| SCHEMBL20454423 | 0.78 | CA2 (0.54) | KMT2AMEN1EPHX1CA2NPC1 | |
| SCHEMBL463120 | 0.77 | MMP2 (0.64) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL4622948 | 0.77 | MMP2 (0.64) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL4622957 | 0.77 | MMP2 (0.64) | KMT2AMEN1NPC1TP53RAB9A | |
| SCHEMBL6891119 | 0.77 | CA2 (0.47) | KMT2AMEN1EPHX1CA2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157004-A1 | REGIOSELECTIVE SYNTHESIS OF DTPA DERIVATIVES | IDEC PHARMACEUTICALS CORPORATION (US) | 2001-11-28 | — | — | EP | claimed |
| US-6207858-B1 | ELIMINATES THE NEED FOR ION EXCHANGE CHROMOTOGRAPHIC SEPARATION OF INTERMEDIATES, USEFUL AS BI-FUNCTIONAL CHELATORS IN RADIOIMMUNOTHERAPY AND IMAGING, DIETHYLENETRIAMINEPENTAACETIC ACID (DTPA), SUITABLE FOR | IDEC PHARMACEUTICALS CORPORATION | 2001-03-27 | — | — | US | claimed |
| WO-2000051976-A1 | REGIOSELECTIVE SYNTHESIS OF DTPA DERIVATIVES | IDEC PHARMACEUTICALS CORPORATION (US) | 2000-09-08 | — | — | WO | claimed |
| EP-1157004-B1 | Composition comprising MX-DTPA and its use to produce a radiolabeled MX-DTPA | BIOGEN IDEC INC (US) | 2008-05-21 | — | — | EP | disclosed |
| EP-1157004-A1 | REGIOSELECTIVE SYNTHESIS OF DTPA DERIVATIVES | IDEC PHARMACEUTICALS CORPORATION (US) | 2001-11-28 | — | — | EP | disclosed |
| US-6207858-B1 | ELIMINATES THE NEED FOR ION EXCHANGE CHROMOTOGRAPHIC SEPARATION OF INTERMEDIATES, USEFUL AS BI-FUNCTIONAL CHELATORS IN RADIOIMMUNOTHERAPY AND IMAGING, DIETHYLENETRIAMINEPENTAACETIC ACID (DTPA), SUITABLE FOR | IDEC PHARMACEUTICALS CORPORATION | 2001-03-27 | — | — | US | disclosed |
| WO-2000051976-A1 | REGIOSELECTIVE SYNTHESIS OF DTPA DERIVATIVES | IDEC PHARMACEUTICALS CORPORATION (US) | 2000-09-08 | — | — | WO | disclosed |