SCHEMBL6891119

SCHEMBL6891119

NC(=O)C(Cc1ccc([N+](=O)[O-])cc1)NC=O

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.47
LMNA P02545 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.44
IDO1 P14902 3/20 0.43
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
TSHR P16473 2/20 0.42
EPHX1 P07099 1/20 0.42
NPC1 O15118 1/20 0.41
TP53 P04637 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
MMP2 P08253 1/20 0.40
MAPT P10636 2/20 0.40
CHRM2 P08172 1/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28052118 0.87 CA2 (0.54) CA2LMNAMEN1KMT2ATSHR
SCHEMBL6575563 0.83 ALDH1A1 (0.46) CA2LMNAMEN1KMT2ANPC1
SCHEMBL16684123 0.82 CA2 (0.49) CA2LMNALOXL2IDO1MEN1
SCHEMBL28209573 0.81 LMNA (0.46) CA2LMNAMEN1KMT2ASMN1; SMN2
SCHEMBL18444555 0.81 CA2 (0.54) CA2LMNALOXL2IDO1MEN1
SCHEMBL20454423 0.81 CA2 (0.54) CA2LMNALOXL2IDO1MEN1
SCHEMBL12698580 0.80 ACE (0.46) CA2
SCHEMBL4095860 0.80 CA2 (0.47) CA2LMNALOXL2IDO1MEN1
SCHEMBL3997596 0.80 TGM2 (0.50) CA2LMNALOXL2IDO1MEN1
SCHEMBL10437254 0.79 CA2 (0.46) CA2LMNALOXL2IDO1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699079-B1 BIOACTIVE AND/OR TARGETED DENDRIMER CONJUGATES COMPRISING GENETIC MATERIALS DOW CHEMICAL CO (US) 2004-09-29 EP disclosed
US-6312679-B1 Dense star polymer conjugates as dyes THE DOW CHEMICAL COMPANY 2001-11-06 US disclosed
US-6177414-B1 POLYMAMINOAMIDE DENDRIMER STAR POLYMER CARRYING SALICYLIC ACID MOIETIES; DRUG DELIVERY THE DOW CHEMICAL COMPANY 2001-01-23 US disclosed
US-5714166-A Bioactive and/or targeted dendrimer conjugates THE DOW CHEMICAL COMPANY (US) 1998-02-03 US disclosed
EP-0271180-B2 Starburst conjugates DOW CHEMICAL CO (US) 1997-06-18 EP disclosed
US-5527524-A AGRICULTURAL, PHARMACEUTICAL, DRUG DELIVERY THE DOW CHEMICAL COMPANY (US) 1996-06-18 US disclosed
EP-0699079-A1 BIOACTIVE AND/OR TARGETED DENDRIMER CONJUGATES THE DOW CHEMICAL COMPANY (US) 1996-03-06 EP disclosed
WO-1995024221-A1 BIOACTIVE AND/OR TARGETED DENDRIMER CONJUGATES THE DOW CHEMICAL COMPANY (US) 1995-09-14 WO disclosed
US-5338532-A Star polymer as carrier for drugs, agricultural compounds THE DOW CHEMICAL COMPANY (US) 1994-08-16 US disclosed
EP-0271180-A1 Starburst conjugates THE DOW CHEMICAL COMPANY (US) 1988-06-15 EP disclosed
WO-1988001178-A1 STARBURST CONJUGATES THE DOW CHEMICAL COMPANY (US) 1988-02-25 WO disclosed
WO-1988001179-A1 STARBURST CONJUGATES THE DOW CHEMICAL COMPANY (US) 1988-02-25 WO disclosed
WO-1988001180-A1 STARBURST CONJUGATES THE DOW CHEMICAL COMPANY (US) 1988-02-25 WO disclosed