Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10437254 | 1.00 | CA2 (0.46) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL4095860 | 0.84 | CA2 (0.47) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL16684123 | 0.81 | CA2 (0.49) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL4622953 | 0.81 | KMT2A (0.46) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL20454423 | 0.80 | CA2 (0.54) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL18444555 | 0.80 | CA2 (0.54) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL6891119 | 0.79 | CA2 (0.47) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL4104155 | 0.78 | LOXL2 (0.50) | CA2LOXL2LMNAMEN1KMT2A | |
| SCHEMBL28944005 | 0.76 | CA2 (0.53) | CA2LMNAMEN1KMT2ATSHR | |
| SCHEMBL28944004 | 0.76 | CA2 (0.53) | CA2LMNAMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6995247-B2 | Ac-HEHA and related compounds, methods of synthesis and methods of use | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-02-07 | — | — | US | disclosed |
| US-20040184991-A1 | Ac-HEHA and related compounds, methods of synthesis and methods of use | THE GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DPT. OF HEALTH AND HUMAN SERVICES | 2004-09-23 | — | — | US | disclosed |
| US-6696551-B1 | RADIOIMMUNOTHERAPY, DECONTAMINATION AND DETOXIFICATION | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2004-02-24 | — | — | US | disclosed |
| WO-2000059896-A1 | 225Ac-HEHA AND RELATED COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-10-12 | — | — | WO | disclosed |
| EP-0355860-A1 | A bifunctional metal chelating agent and a precursor compound | GANSOW, Otto A. (US) | 1990-02-28 | — | — | EP | disclosed |
| EP-0315220-A1 | Method of forming a metal chelate protein conjugate | GANSOW, Otto A. (US) | 1989-05-10 | — | — | EP | disclosed |
| US-4824986-A | Metal chelate protein conjugate | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1989-04-25 | — | — | US | disclosed |
| EP-0220279-A1 | METHOD OF FORMING A METAL CHELATE PROTEIN CONJUGATE | GANSOW, Otto A. (US) | 1987-05-06 | — | — | EP | disclosed |
| WO-1986006384-A1 | METHOD OF FORMING A METAL CHELATE PROTEIN CONJUGATE | GANSOW OTTO A (US) | 1986-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040184991-A1 | Ac-HEHA and related compounds, methods of synthesis and methods of use | APEH, DOHH, DDAH1 | CA2 678/4885LOXL2 4721/4885LMNA 2326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.