Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 7/20 | 0.34 |
| ▸ | FAP | Q12884 | 4/20 | 0.34 |
| ▸ | PREP | P48147 | 3/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 4/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623157 | 1.00 | POLB (0.34) | POLBL3MBTL1DPP4FAPPREP | |
| SCHEMBL27368424 | 0.82 | POLB (0.35) | POLBL3MBTL1DPP4FAPPREP | |
| SCHEMBL2707073 | 0.80 | CA2 (0.39) | POLBL3MBTL1DPP4FAPPREP | |
| SCHEMBL21807152 | 0.80 | DPP4 (0.37) | POLBL3MBTL1DPP4FAPPREP | |
| SCHEMBL4893081 | 0.74 | GAA (0.36) | POLBL3MBTL1DPP4FAPPREP | |
| SCHEMBL4624823 | 0.74 | HSD17B10 (0.47) | — | |
| SCHEMBL26984528 | 0.72 | RAB9A (0.38) | L3MBTL1CA2ACE | |
| SCHEMBL27094468 | 0.71 | GAA (0.33) | L3MBTL1DPP4FAPPREPCA2 | |
| SCHEMBL10525888 | 0.68 | ACE (0.35) | POLBL3MBTL1DPP4FAPPREP | |
| SCHEMBL5171312 | 0.67 | ALDH1A1 (0.50) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948597-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007050522-A1 | DERIVATIVES FOR MODULATION OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-03 | — | — | WO | disclosed |