Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.43 |
| ▸ | EPOR | P19235 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623232 | 0.81 | HTR7 (0.38) | ALDH1A1LMNASMN1; SMN2TRPM8MCHR1 | |
| SCHEMBL4623713 | 0.76 | TRPM8 (0.46) | ALOX5EPORALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2247401 | 0.75 | EPOR (0.44) | ALOX5EPORALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7908388 | 0.68 | KAT6A (0.41) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7908386 | 0.68 | KAT6A (0.41) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL4369267 | 0.67 | SRD5A2 (0.46) | ALDH1A1LMNATRPM8MCHR1 | |
| SCHEMBL2247555 | 0.67 | HPGDS (0.65) | ALDH1A1LMNASMN1; SMN2AKR1C3 | |
| SCHEMBL5651552 | 0.67 | TRPM8 (0.45) | ALDH1A1LMNASMN1; SMN2TRPM8 | |
| SCHEMBL7908883 | 0.66 | NPC1 (0.45) | SMN1; SMN2OPRM1KCNH2 | |
| SCHEMBL7908877 | 0.66 | NPC1 (0.45) | SMN1; SMN2OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |