Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | EPOR | P19235 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4650065 | 0.87 | TRPM8 (0.44) | TRPM8EPORAKR1C3PTGESF10 | |
| SCHEMBL27826145 | 0.86 | TRPM8 (0.46) | TRPM8EPORPPARGMEN1KMT2A | |
| SCHEMBL5650478 | 0.85 | TRPM8 (0.50) | TRPM8PPARGPTGESMEN1KMT2A | |
| SCHEMBL5653525 | 0.84 | SRD5A2 (0.44) | PTGESLPAR1FFAR1FFAR4PARP10 | |
| SCHEMBL5650382 | 0.79 | MEN1 (0.46) | LPAR1MEN1KMT2A | |
| SCHEMBL5650668 | 0.79 | HPGDS (0.45) | TRPM8PPARGFFAR1FFAR4 | |
| SCHEMBL5652505 | 0.78 | KMT2A (0.40) | TRPM8EPORPPARGALDH1A1LMNA | |
| SCHEMBL4623203 | 0.78 | NPC1 (0.43) | TRPM8PPARGALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL2247401 | 0.78 | EPOR (0.44) | EPORAKR1C3F10TNKSPARP15 | |
| SCHEMBL5653109 | 0.77 | SRD5A2 (0.47) | LPAR1FFAR1FFAR4PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | claimed |