Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.67 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.67 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | RECQL | P46063 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.67 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.67 |
| ▸ | THPO | P40225 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | GSR | P00390 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| R-Ketoprofen SCHEMBL22115432 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL8582246 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Dexketoprofen SCHEMBL9057021 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Dexketoprofen SCHEMBL1230721 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL1229874 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL29468213 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| R-Ketoprofen SCHEMBL22115435 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Dexketoprofen SCHEMBL22115428 | 1.00 | PTGS1 (0.67) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Ketoprofen SCHEMBL22115430 | 0.99 | PTGS1 (0.65) | PTGS1PTGS2MAPTALDH1A1CXCR1 | |
| Lysine SCHEMBL29438093 | 0.86 | GSR (0.61) | PTGS1PTGS2MAPTCXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12582624-B2 | Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical compositions and their medical use | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2026-03-24 | — | — | US | claimed |
| EP-4138807-B1 | CO-CRYSTAL OF GABAPENTIN, KETOPROFEN AND LYSINE, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | DOMPE FARM SPA (IT) | 2025-10-08 | — | — | EP | claimed |
| EP-4161899-B1 | CO-CRYSTAL OF KETOPROFEN, LYSINE AND GABAPENTIN | DOMPE FARM SPA (IT) | 2025-10-08 | — | — | EP | claimed |
| US-12365644-B2 | Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use | DOMPÈ FARMACEUTICI S.P.A. (IT) | 2025-07-22 | — | — | US | claimed |
| US-20230357121-A1 | CO-CRYSTAL OF KETOPROFEN, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2023-11-09 | — | — | US | claimed |
| US-20230181507-A1 | CO-CRYSTAL OF GABAPENTIN, KETOPROFEN AND LYSINE, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2023-06-15 | — | — | US | claimed |
| EP-4161899-A1 | CO-CRYSTAL OF KETOPROFEN, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | Dompe' Farmaceutici SpA (IT) | 2023-04-12 | — | — | EP | claimed |
| CN-111587108-B | Immediate release pharmaceutical compositions comprising ketoprofen lysine salt | 多姆皮制药公司 | 2023-03-28 | — | — | CN | claimed |
| EP-4138807-A1 | CO-CRYSTAL OF GABAPENTIN, KETOPROFEN AND LYSINE, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | Dompe' Farmaceutici SpA (IT) | 2023-03-01 | — | — | EP | claimed |
| CN-115697316-A | Synergistic admixture of gabapentin and ketoprofen, pharmaceutical composition and medical uses thereof | 东佩制药股份公司 | 2023-02-03 | — | — | CN | claimed |
| CN-115697315-A | Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical composition and medical application thereof | 东佩制药股份公司 | 2023-02-03 | — | — | CN | claimed |
| CN-115605455-A | Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical composition and medical application thereof | 东佩制药股份公司（IT） | 2023-01-13 | — | — | CN | claimed |
| EP-0703893-A1 | SALTS OF 2-(3-BENZOYLPHENYL) PROPIONIC ACID WITH ACHIRAL AND CHIRAL ORGANIC BASES AND PHARMACEUTICAL COMPOSITIONS THEREOF | DOMPE FARMACEUTICI S.P.A. (IT) | 1996-04-03 | — | — | EP | claimed |
| WO-1994020449-A1 | SALTS OF 2-(3-BENZOYLPHENYL)PROPIONIC ACID WITH ACHIRAL AND CHIRAL ORGANIC BASES AND PHARMACEUTICAL COMPOSITIONS THEREOF | DOMPE'FARMACEUTICI SPA (IT) | 1994-09-15 | — | — | WO | claimed |
| US-12582624-B2 | Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical compositions and their medical use | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2026-03-24 | — | — | US | disclosed |
| US-12528760-B2 | Co-crystal of ketoprofen and its preparation, pharmaceutical compositions comprising the same and uses thereof | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2026-01-20 | — | — | US | disclosed |
| EP-4662248-A2 | SHEAR STABLE AQUEOUS FLUOROPOLYMER DISPERSION | Arkema, Inc. (US) | 2025-12-17 | — | — | EP | disclosed |
| US-5808069-A | Salts of 2-(3-benzoylphenyl) propionic acid with organic bases and pharmaceutical compositions thereof | DOMPE' FARMACEUTICI SPA (IT) | 1998-09-15 | — | — | US | disclosed |
| EP-0703893-A1 | SALTS OF 2-(3-BENZOYLPHENYL) PROPIONIC ACID WITH ACHIRAL AND CHIRAL ORGANIC BASES AND PHARMACEUTICAL COMPOSITIONS THEREOF | DOMPE FARMACEUTICI S.P.A. (IT) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994020449-A1 | SALTS OF 2-(3-BENZOYLPHENYL)PROPIONIC ACID WITH ACHIRAL AND CHIRAL ORGANIC BASES AND PHARMACEUTICAL COMPOSITIONS THEREOF | DOMPE'FARMACEUTICI SPA (IT) | 1994-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230181507-A1 | CO-CRYSTAL OF GABAPENTIN, KETOPROFEN AND LYSINE, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | GABARAP, GABRA5, GABARAPL1 | PTGS1 266/4885PTGS2 356/4885MAPT 73/4885 |
| US-12582624-B2 | Co-crystal of gabapentin, ketoprofen and lysine, pharmaceutical compositions and their medical use | CRYZ, S100P, OPRK1 | PTGS1 650/4885PTGS2 586/4885MAPT 119/4885 |
| US-20230357121-A1 | CO-CRYSTAL OF KETOPROFEN, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | GABARAP, GABRA5, KMO | PTGS1 204/4885PTGS2 288/4885MAPT 68/4885 |
| US-12365644-B2 | Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use | GABARAP, GABRA5, KMO | PTGS1 204/4885PTGS2 288/4885MAPT 68/4885 |
| US-12528760-B2 | Co-crystal of ketoprofen and its preparation, pharmaceutical compositions comprising the same and uses thereof | KMO, KCNK5, KLK5 | PTGS1 204/4885PTGS2 362/4885MAPT 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.