Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | EPOR | P19235 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623713 | 0.87 | TRPM8 (0.46) | TRPM8F10AKR1C3EPORFFAR1 | |
| SCHEMBL4371351 | 0.78 | KMT2A (0.40) | TRPM8KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3578758 | 0.78 | PTGES (0.51) | FFAR1PTGESLPAR1ALOX5LPAR5 | |
| SCHEMBL3584964 | 0.77 | F7 (0.44) | TRPM8F10PTGESALOX5 | |
| SCHEMBL3577149 | 0.77 | FFAR1 (0.48) | FFAR1PTGESPARP10ALOX5 | |
| SCHEMBL3588588 | 0.77 | ALOX5 (0.52) | EPORFFAR1PTGESPARP10ALOX5 | |
| SCHEMBL3591193 | 0.77 | ADAMTS4 (0.41) | TRPM8PTGES | |
| SCHEMBL3585006 | 0.76 | ACACB (0.44) | TRPM8FFAR1PTGESKMT2AMEN1 | |
| SCHEMBL3584344 | 0.75 | MAOB (0.53) | PTGESPARP10ALOX5 | |
| SCHEMBL3589183 | 0.75 | PARP15 (0.53) | FFAR1PTGESPARP15PARP14PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | disclosed |