Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP10 | P09238 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4362591 | 0.91 | HPGDS (0.49) | HPGDSPSMB5TRPM8FFAR1MMP12 | |
| SCHEMBL5650478 | 0.88 | TRPM8 (0.50) | HPGDSTRPM8MMP12MMP2MMP8 | |
| SCHEMBL27826145 | 0.82 | TRPM8 (0.46) | TRPM8HDAC3HDAC1PPARG | |
| SCHEMBL4623713 | 0.79 | TRPM8 (0.46) | TRPM8FFAR1FFAR4PPARG | |
| SCHEMBL4361259 | 0.78 | TRPM8 (0.53) | HPGDSTRPM8FFAR1MMP12 | |
| SCHEMBL2246723 | 0.78 | MMP12 (0.44) | HPGDSTRPM8DRD2DRD4MMP12 | |
| SCHEMBL5655902 | 0.77 | MMP12 (0.43) | HPGDSTRPM8MMP12MMP2MMP8 | |
| SCHEMBL5652505 | 0.74 | KMT2A (0.40) | TRPM8HDAC3HDAC1PPARG | |
| SCHEMBL4623203 | 0.74 | NPC1 (0.43) | TRPM8PPARG | |
| SCHEMBL2248314 | 0.74 | HPGDS (0.68) | HPGDSDRD2DRD4HTR2AMMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | HPGDS 1417/4885PSMB5 2033/4885TRPM8 1187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.