Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.44 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046023 | 0.88 | ACE (0.60) | SMN1; SMN2ACEMRGPRX4CTSK | |
| SCHEMBL2247559 | 0.87 | ALDH1A1 (0.58) | GPR132ALDH1A1LMNASMN1; SMN2HDAC8 | |
| SCHEMBL4623549 | 0.86 | ALDH1A1 (0.53) | GPR132ALDH1A1LMNASMN1; SMN2HDAC8 | |
| SCHEMBL7709356 | 0.83 | ACE (0.50) | SMN1; SMN2ACEMRGPRX4HPGDS | |
| SCHEMBL2247402 | 0.82 | ALDH1A1 (0.51) | GPR132ALDH1A1LMNASMN1; SMN2HDAC8 | |
| SCHEMBL5652507 | 0.80 | ACE (0.52) | ALDH1A1LMNASMN1; SMN2ACEMRGPRX4 | |
| SCHEMBL4621148 | 0.80 | MAPT (0.55) | ALDH1A1LMNASMN1; SMN2ACEHPGDS | |
| SCHEMBL2247555 | 0.80 | HPGDS (0.65) | GPR132ALDH1A1LMNASMN1; SMN2HDAC8 | |
| SCHEMBL2246727 | 0.78 | HPGDS (0.51) | ACEMRGPRX4HPGDSCTSK | |
| SCHEMBL29682481 | 0.78 | MME (0.56) | SMN1; SMN2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | claimed |