Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | PTPRC | P08575 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248134 | 0.90 | POLB (0.52) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL4623235 | 0.86 | RAB9A (0.43) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL2249427 | 0.86 | CA2 (0.59) | MAPTNPC1RAB9AALDH1A1PTPRC | |
| SCHEMBL7046023 | 0.84 | ACE (0.60) | NPC1RAB9ASMN1; SMN2ACECTSL | |
| SCHEMBL7709356 | 0.84 | ACE (0.50) | SMN1; SMN2ACECA2CA1F10 | |
| SCHEMBL2246525 | 0.83 | NPC1 (0.43) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL4622940 | 0.82 | BCHE (0.44) | NPC1RAB9APTPRCCA2CA1 | |
| SCHEMBL2244945 | 0.82 | PTPRC (0.47) | MAPTNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL5652507 | 0.81 | ACE (0.52) | ALDH1A1LMNASMN1; SMN2ACECTSL | |
| SCHEMBL4623715 | 0.80 | GPR132 (0.53) | ALDH1A1LMNASMN1; SMN2ACEHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902014-A2 | GLUTAMATE AGGRECANASE INHIBITORS | Wyeth (US) | 2008-03-26 | — | — | EP | claimed |
| WO-2007008994-A2 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2007-01-18 | — | — | WO | claimed |