Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | KIF11 | P52732 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31388334 | 0.88 | MAPT (0.55) | MAPTKDM4EKIF11HTTLMNA | |
| SCHEMBL455344 | 0.83 | IDO1 (0.78) | IDO1MAPTKDM4EGAAMEN1 | |
| SCHEMBL457226 | 0.81 | IDO1 (0.65) | IDO1MAPTKDM4EKIF11HTT | |
| SCHEMBL28649815 | 0.81 | ALDH1A1 (0.65) | MAPTHTTLMNAALOX12GAA | |
| SCHEMBL17465537 | 0.81 | HTT (0.68) | MAPTKIF11HTTLMNAALOX12 | |
| SCHEMBL4348957 | 0.80 | KIF11 (0.59) | MAPTKIF11HTTLMNAALOX12 | |
| SCHEMBL23453330 | 0.78 | LMNA (0.58) | MAPTKDM4EHTTLMNAALOX12 | |
| SCHEMBL455272 | 0.78 | IDO1 (0.64) | IDO1MAPTKDM4EHTTGAA | |
| SCHEMBL9037064 | 0.77 | NPC1 (0.66) | MAPTKIF11HTTLMNAMEN1 | |
| SCHEMBL25494628 | 0.77 | LMNA (0.57) | MAPTHTTLMNAALOX12GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026021-A2 | TRKA AS A TARGET FOR INHIBITING APP CLEAVAGE AND/OR PROGRESSION OF ALZHEIMER'S DISEASE | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2013-02-21 | — | — | WO | disclosed |
| WO-2012033601-A1 | THIOSEMICARBAZONES WITH MDR1 - INVERSE ACTIVITY | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2012-03-15 | — | — | WO | disclosed |