Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SLC25A5 | P05141 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4912246 | 0.81 | CES2 (0.45) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL6387274 | 0.81 | HDAC3 (0.52) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL15627453 | 0.78 | HDAC4 (0.58) | HDAC4HDAC7HDAC5HTR2A | |
| SCHEMBL8470104 | 0.77 | POLB (0.51) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL7043488 | 0.77 | HDAC3 (0.57) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL27558512 | 0.77 | HDAC3 (0.61) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL1419881 | 0.76 | CYP1A2 (0.55) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL21172113 | 0.75 | HDAC3 (0.46) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| Benzene SCHEMBL28538497 | 0.75 | HDAC3 (0.59) | HDAC3HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL30001332 | 0.75 | HDAC3 (0.59) | HDAC3HDAC4HDAC7HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016172631-A2 | SUBSTRATE SELECTIVE INHIBITORS OF INSULIN-DEGRADING ENZYME (IDE) AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-10-27 | — | — | WO | disclosed |
| US-20120289457-A1 | PEPTIDE OLIGONUCLEOTIDE CONJUGATES | AVI BIOPHARMA, INC. (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120065169-A1 | OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS | JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT | 2012-03-15 | — | — | US | disclosed |
| US-20120010361-A1 | CURABLE COMPOSITION AND CURED PRODUCT THEREOF | SHOWA DENKO K.K. (JP) | 2012-01-12 | — | — | US | disclosed |
| US-20110294948-A1 | AROMATIC GROUP-CONTAINING (METH) ACRYLATE COMPOUND | SHOWA DENKO K.K. (JP) | 2011-12-01 | — | — | US | disclosed |
| US-20100249111-A1 | MULTI-RING COMPOUNDS AND USES THEREOF | AVALON PHARMACEUTICALS (US) | 2010-09-30 | — | — | US | disclosed |
| US-20090036429-A1 | Hydroxypiperidine Derivatives and Uses Thereof | AVALON PHARMACEUTICALS | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065169-A1 | OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS | NSUN2, UPF1, RTCB | HDAC3 1297/4885HDAC4 1413/4885HDAC7 1310/4885 |
| US-20110294948-A1 | AROMATIC GROUP-CONTAINING (METH) ACRYLATE COMPOUND | ACR, MMAB, ATR | HDAC3 3508/4885HDAC4 3509/4885HDAC7 3847/4885 |
| US-20100249111-A1 | MULTI-RING COMPOUNDS AND USES THEREOF | TP53, BCOR, HPGDS | HDAC3 542/4885HDAC4 337/4885HDAC7 349/4885 |
| US-20120289457-A1 | PEPTIDE OLIGONUCLEOTIDE CONJUGATES | SNRPE, SMN1; SMN2, UPF1 | HDAC3 4190/4885HDAC4 4113/4885HDAC7 3673/4885 |
| US-20090036429-A1 | Hydroxypiperidine Derivatives and Uses Thereof | HPGDS, HPGD, DPYD | HDAC3 756/4885HDAC4 279/4885HDAC7 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.