Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL272884 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL4626269 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL2342320 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL272885 | 1.00 | TSHR (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL5676045 | 0.97 | TSHR (0.53) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL4603810 | 0.97 | TSHR (0.53) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL4603806 | 0.97 | TSHR (0.53) | TSHRTP53EGLN1EGLN3LMNA | |
| Vinyl Ether SCHEMBL9322572 | 0.87 | HCAR2 (0.46) | TSHRTP53EGLN1EGLN3LMNA | |
| Vinyl Ether SCHEMBL8967458 | 0.85 | HCAR2 (0.44) | TSHRTP53EGLN1EGLN3LMNA | |
| Vinyl Ether SCHEMBL27430610 | 0.85 | HCAR2 (0.44) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1447217-B1 | Heat-sensitive lithographic printing plate | FUJIFILM CORP (JP) | 2008-06-18 | — | — | EP | disclosed |
| US-7101649-B2 | Heat-sensitive lithographic printing plate | FUJI PHOTO FILM CO., LTD. (JP) | 2006-09-05 | — | — | US | disclosed |
| US-20040166431-A1 | Heat-sensitive lithographic printing plate | FUJIFILM CORPORATION (JP) | 2004-08-26 | — | — | US | disclosed |
| EP-1447217-A2 | Heat-sensitive lithographic printing plate | FUJI PHOTO FILM CO., LTD. (JP) | 2004-08-18 | — | — | EP | disclosed |