Fumaric Acid

Fumaric Acid

SCHEMBL272885

C=COC=C.O=C(O)C=CC(=O)O

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.32
KMT2A known ✓ Q03164 1/20 0.32
TSHR P16473 4/20 0.56
TP53 P04637 1/20 0.56
EGLN1 Q9GZT9 1/20 0.56
EGLN3 Q9H6Z9 1/20 0.56
LMNA P02545 2/20 0.44
HCAR2 Q8TDS4 7/20 0.43
ALDH1A1 P00352 3/20 0.33
GABRR1 P24046 2/20 0.33
GABRR2 P28476 2/20 0.33
BLM P54132 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
ALOX15 P16050 2/20 0.33
RECQL P46063 2/20 0.33
HSD17B10 Q99714 2/20 0.33
GAA P10253 1/20 0.33
GABRR3 A8MPY1 1/20 0.33
APEX1 P27695 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maleic Acid SCHEMBL272884 1.00 TSHR (0.56) TSHRTP53EGLN1EGLN3LMNA
Fumaric Acid SCHEMBL4626269 1.00 TSHR (0.56) TSHRTP53EGLN1EGLN3LMNA
Fumaric Acid SCHEMBL2342320 1.00 TSHR (0.56) TSHRTP53EGLN1EGLN3LMNA
Maleic Acid SCHEMBL4626935 1.00 TSHR (0.56) TSHRTP53EGLN1EGLN3LMNA
Fumaric Acid SCHEMBL5676045 0.97 TSHR (0.53) TSHRTP53EGLN1EGLN3LMNA
Fumaric Acid SCHEMBL4603810 0.97 TSHR (0.53) TSHRTP53EGLN1EGLN3LMNA
Maleic Acid SCHEMBL4603806 0.97 TSHR (0.53) TSHRTP53EGLN1EGLN3LMNA
Vinyl Ether SCHEMBL9322572 0.87 HCAR2 (0.46) TSHRTP53EGLN1EGLN3LMNA
Vinyl Ether SCHEMBL8967458 0.85 HCAR2 (0.44) TSHRTP53EGLN1EGLN3LMNA
Vinyl Ether SCHEMBL27430610 0.85 HCAR2 (0.44) TSHRTP53EGLN1EGLN3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 344 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4301713-A1 USE OF FOAM MORTAR AS ADHESIVE FOR FLOORINGS Wacker Chemie AG (DE) 2024-01-10 EP claimed
CN-112055901-B Negative electrode slurry for lithium secondary battery and preparation method thereof 株式会社LG新能源 2023-10-03 CN claimed
EP-4118056-A1 PROCESSES FOR PRODUCING FOAMED CONCRETE Wacker Chemie AG (DE) 2023-01-18 EP claimed
CN-112055901-A Negative electrode slurry for lithium secondary battery and preparation method thereof 株式会社LG化学 2020-12-08 CN claimed
CN-103687830-B Method and additive for improving adhesion of a composition to a substrate 阿克佐诺贝尔化学国际公司 2016-08-17 CN claimed
CN-102781869-B Method and additive for improving adhesion of building compositions to substrates AKZO NOBEL CHEMICALS INTERNATIONAL B.V. (NL) 2015-08-05 CN claimed
CN-103415538-B Method for producing polymers by emulsion or suspension polymerization in a jet loop reactor WACKER CHEMIE AG 2015-07-15 CN claimed
US-20070082754-A1 Golf ball comprising UV-cured non-surface layer ACUSHNET COMPANY 2007-04-12 US claimed
US-6893763-B2 Composite polymer electrolyte membrane for polymer electrolyte membrane fuel cells GAS TECHNOLOGY INSTITUTE (US) 2005-05-17 US claimed
WO-2003090304-A1 COMPOSITE POLYMER ELECTROLYTE MEMBRANE FOR POLYMER ELECTROLYTE MEMBRANE FUEL CELLS GAS TECHNOLOGY INSTITUTE (US) 2003-10-30 WO claimed
EP-0651652-B1 TREATMENT FOR SENSITIVE TEETH UNIV MELBOURNE (AU) 2000-02-09 EP claimed
US-5981475-A DENTINAL HYPERSENSITIVITY REDUCING AGENT CONTAINING A CASEIN, A COMPONENT OF CASEIN, A PHOSPHOPROTEIN AND A PHOSPHOPEPTIDE, COMPRISING AMINO ACYL RESIDUES OF PHOSPHOSERIN, PHOSPHOLYSIN,POHSOPHOTHREONINE, PHOSPHOTYROSINE, THE UNIVERSITY OF MELBOURNE (AU) 1999-11-09 US claimed
US-5750591-A MIXED PARTIAL SALT OF ALKYL VINYL ETHER-MALEIC ACID COPOLYMER THE BLOCK DRUG COMPANY (US) 1998-05-12 US claimed
EP-0651652-A4 TREATMENT FOR SENSITIVE TEETH. UNIV MELBOURNE (AU) 1996-10-23 EP claimed
EP-0651633-A1 PHOSPHOPEPTIDES FOR THE TREATMENT OF DENTAL CALCULUS THE UNIVERSITY OF MELBOURNE (AU) 1995-05-10 EP claimed
EP-0651652-A1 TREATMENT FOR SENSITIVE TEETH THE UNIVERSITY OF MELBOURNE (AU) 1995-05-10 EP claimed
EP-0651633-A4 PHOSPHOPEPTIDES FOR THE TREATMENT OF DENTAL CALCULUS. UNIV MELBOURNE (AU) 1994-08-01 EP claimed
WO-1994000146-A1 TREATMENT FOR SENSITIVE TEETH THE UNIVERSITY OF MELBOURNE (AU) 1994-01-06 WO claimed
US-5227154-A Casein derivatives, phosphoserine, glutamic acid THE UNIVERSITY OF MELBOURNE (AU) 1993-07-13 US claimed
WO-1993003707-A1 PHOSPHOPEPTIDES FOR THE TREATMENT OF DENTAL CALCULUS THE UNIVERSITY OF MELBOURNE (AU) 1993-03-04 WO claimed