Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070002 | 0.89 | IRAK4 (0.44) | IRAK4CRHR1CTSSCTSKNOS2 | |
| SCHEMBL2069540 | 0.72 | CRHR1 (0.42) | CRHR1HTR7 | |
| SCHEMBL25015240 | 0.70 | NOS1 (0.40) | CRHR1NOS2NOS1HTR7 | |
| SCHEMBL2070847 | 0.70 | NOS1 (0.40) | CRHR1NOS2NOS1HTR7 | |
| SCHEMBL2071875 | 0.69 | HTR7 (0.36) | CRHR1NOS2NOS1HTR7 | |
| SCHEMBL3623211 | 0.69 | CCR1 (0.42) | CRHR1NOS2NOS1HTR7 | |
| SCHEMBL2070175 | 0.68 | LTB4R (0.34) | IRAK4CRHR1NOS2NOS1GAA | |
| SCHEMBL2070288 | 0.68 | CRHR1 (0.36) | CRHR1NOS2NOS1HTR7 | |
| SCHEMBL31655443 | 0.67 | CCR1 (0.46) | CRHR1NOS2NOS1HTR7 | |
| SCHEMBL1426671 | 0.65 | MEN1 (0.50) | IRAK4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |