Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 8/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 8/20 | 0.60 |
| ▸ | DHODH | Q02127 | 1/20 | 0.58 |
| ▸ | PYGL | P06737 | 2/20 | 0.54 |
| ▸ | PYGM | P11217 | 2/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 5/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629285 | 0.82 | DHODH (0.55) | TAS1R3TAS1R1DHODHTAS1R2PDE4A | |
| SCHEMBL6163049 | 0.75 | PDPK1 (0.59) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL705805 | 0.75 | TAS1R3 (1.00) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL4628661 | 0.74 | OPRM1 (0.48) | TAS1R3TAS1R1DHODHPYGLPYGM | |
| SCHEMBL5923923 | 0.71 | TAS1R3 (0.86) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL5923929 | 0.71 | TAS1R3 (0.86) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL6361268 | 0.71 | ALDH1A1 (0.85) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL191727 | 0.71 | HTT (0.60) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL3421659 | 0.71 | HTT (0.60) | TAS1R3TAS1R1TAS1R2PDE4APDE4B | |
| SCHEMBL191726 | 0.71 | HTT (0.60) | TAS1R3TAS1R1TAS1R2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1918272-A1 | Pharmaceutically active compounds and methods of use | Wyeth a Corporation of the State of Delaware (US) | 2008-05-07 | — | — | EP | disclosed |
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-11-30 | — | — | US | disclosed |
| US-7041702-B1 | Pharmaceutically active compounds and methods of use | SCION PHARMACEUTICALS, INC. (US) | 2006-05-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270741-A1 | Pharmaceutically active compounds and methods of use | GBA1, CTSA, GAA | TAS1R3 4271/4885TAS1R1 4326/4885DHODH 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.