Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071875 | 0.94 | HTR7 (0.36) | HTR7CRHR1NOS1NOS2GPBAR1 | |
| SCHEMBL2070847 | 0.85 | NOS1 (0.40) | HTR7CRHR1NOS1NOS2ALDH1A1 | |
| SCHEMBL12640990 | 0.78 | HTR7 (0.40) | HTR7NOS1NOS2FFAR1ALDH1A1 | |
| SCHEMBL12577773 | 0.74 | HTR7 (0.44) | HTR7NOS1NOS2ALDH1A1 | |
| SCHEMBL25015240 | 0.70 | NOS1 (0.40) | HTR7CRHR1NOS1NOS2ALDH1A1 | |
| SCHEMBL2070175 | 0.70 | LTB4R (0.34) | HTR7CRHR1NOS1NOS2ALDH1A1 | |
| SCHEMBL2070288 | 0.70 | CRHR1 (0.36) | HTR7CRHR1NOS1NOS2FFAR1 | |
| SCHEMBL2069540 | 0.69 | CRHR1 (0.42) | HTR7CRHR1 | |
| SCHEMBL3623211 | 0.69 | CCR1 (0.42) | HTR7CRHR1NOS1NOS2ALDH1A1 | |
| SCHEMBL12577789 | 0.68 | CA12 (0.34) | HTR7FFAR1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732541-A4 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL (JP) | 2008-03-05 | — | — | EP | disclosed |
| EP-1732541-A2 | CYCLIC COMPOUNDS | Takeda Pharmaceutical Company Limited (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005099688-A2 | CYCLIC COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-10-27 | — | — | WO | disclosed |