SCHEMBL4629620

SCHEMBL4629620

CC1CN(C(=O)Oc2ccsc2)CCN1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 1/20 0.40
GAA P10253 1/20 0.39
REN P00797 1/20 0.38
TP53 P04637 1/20 0.37
MDM2 Q00987 1/20 0.37
MMP2 P08253 2/20 0.36
MMP9 P14780 2/20 0.36
MMP12 P39900 2/20 0.36
MMP1 P03956 1/20 0.36
ALDH1A1 P00352 1/20 0.36
POLB P06746 1/20 0.36
PLD1 Q13393 2/20 0.35
HRH3 Q9Y5N1 2/20 0.35
PLD2 O14939 1/20 0.35
CYP1A2 P05177 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
SCN9A Q15858 3/20 0.34
SCN10A Q9Y5Y9 1/20 0.34
CHRNA7 P36544 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4336868 0.81 GAA (0.60) HRH4GAARENTP53ALDH1A1
SCHEMBL17477186 0.75 SCN9A (0.42) HRH4GAARENTP53MDM2
SCHEMBL31112011 0.74 MLNR (0.50) HRH4GAARENALDH1A1HRH3
SCHEMBL15360065 0.70 CHRNB2 (0.47) HRH4RENTP53MDM2PLD1
SCHEMBL4332763 0.70 CHRNB2 (0.47) HRH4RENTP53MDM2PLD1
SCHEMBL15360066 0.70 CHRNB2 (0.47) HRH4RENTP53MDM2PLD1
SCHEMBL28384237 0.69 HRH4 (0.39) HRH4RENTP53MDM2SCN9A
SCHEMBL15359953 0.69 BIRC2 (0.42) HRH4RENTP53MDM2PLD1
Hydrochloric Acid SCHEMBL17560335 0.69 CHRNB2 (0.46) HRH4RENTP53MDM2CYP1A2
SCHEMBL23981850 0.68 GPR119 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1919907-A2 HETEROCYCLIC COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-05-14 EP disclosed
EP-1869025-A1 PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-12-26 EP disclosed
WO-2007026959-A2 DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-03-08 WO disclosed
WO-2006112464-A1 PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-10-26 WO disclosed