Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630003 | 0.76 | P2RX7 (0.36) | TAAR1POLB | |
| SCHEMBL4630163 | 0.66 | TAAR1 (0.32) | TAAR1 | |
| SCHEMBL15537060 | 0.64 | SLC6A2 (0.49) | SIGMAR1SLC6A2SLC6A4SLC6A3CYP1A2 | |
| SCHEMBL16033870 | 0.63 | AKT2 (0.50) | SIGMAR1IDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1221854 | 0.61 | SLC6A2 (0.54) | SIGMAR1SLC6A2SLC6A4SLC6A3PRMT5 | |
| SCHEMBL12586345 | 0.61 | SIGMAR1 (0.44) | SIGMAR1SLC6A2SLC6A4SLC6A3PNMT | |
| SCHEMBL3300581 | 0.59 | TSHR (0.58) | SIGMAR1IDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12585409 | 0.59 | AKT2 (0.46) | SLC6A2SLC6A4SLC6A3PNMTTAAR1 | |
| SCHEMBL3298586 | 0.59 | IDO1 (0.64) | SIGMAR1IDO1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1822591 | 0.58 | MAOA (0.48) | PNMTTAAR1CYP2D6HIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | claimed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | claimed |
| EP-1981497-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007085557-A2 | USE OF SUBSTITUTED 2-IMIDAZOLE OF IMIDAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-02 | — | — | WO | disclosed |