SCHEMBL4630022

SCHEMBL4630022

CCOC(=O)C(=O)C1CCCNC1

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC6A1 P30531 2/20 0.50
SLC6A11 P48066 1/20 0.50
TSHR P16473 1/20 0.50
LMNA P02545 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
SLC6A13 Q9NSD5 1/20 0.50
MAPT P10636 3/20 0.49
KDM4E B2RXH2 1/20 0.49
KMT2A Q03164 1/20 0.49
ATM Q13315 1/20 0.49
CYP2D6 P10635 1/20 0.49
NOS2 P35228 1/20 0.41
PKM P14618 1/20 0.39
ALDH1A1 P00352 2/20 0.37
ALOX15 P16050 1/20 0.36
GAA P10253 1/20 0.36
CPN1 P15169 1/20 0.34
CPB2 Q96IY4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21295502 0.84 SLC6A1 (0.47) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
SCHEMBL132089 0.83 SLC6A1 (0.53) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
SCHEMBL134525 0.83 SLC6A1 (0.53) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
SCHEMBL132090 0.83 SLC6A1 (0.53) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL205293 0.81 SLC6A1 (0.52) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL22444028 0.81 SLC6A1 (0.52) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
Hydrochloric Acid SCHEMBL5215224 0.81 SLC6A1 (0.52) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
SCHEMBL4757302 0.81 SLC6A1 (0.55) SLC6A1SLC6A11TSHRLMNASMN1; SMN2
SCHEMBL873425 0.80 ALDH1A1 (0.44) LMNASMN1; SMN2MAPTKMT2AALDH1A1
SCHEMBL165885 0.80 ALDH1A1 (0.49) SMN1; SMN2MAPTKMT2AATMALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1919907-A2 HETEROCYCLIC COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-05-14 EP disclosed
WO-2007026959-A2 DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-03-08 WO disclosed