SCHEMBL4630138

SCHEMBL4630138

O=C(O)C(NC(c1ccccc1)c1ccccc1)c1ccsc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.45
SLC6A9 P48067 1/20 0.42
SLC6A5 Q9Y345 1/20 0.42
IDO1 P14902 1/20 0.41
TDO2 P48775 1/20 0.41
MTOR P42345 1/20 0.40
RAB9A P51151 1/20 0.40
GRM7 Q14831 1/20 0.40
TSHR P16473 2/20 0.39
CYP3A4 P08684 1/20 0.39
ALOX15 P16050 1/20 0.39
SLC6A2 P23975 1/20 0.39
SLC6A3 Q01959 1/20 0.39
HPGD P15428 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP2D6 P10635 1/20 0.37
SRC P12931 1/20 0.37
ALOX5 P09917 1/20 0.36
NAALAD2 Q9Y3Q0 1/20 0.36
LMNA P02545 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4610111 0.82 CYP2D6 (0.48) MTORRAB9AGRM7TSHRCYP3A4
SCHEMBL4610114 0.82 CYP2D6 (0.48) MTORRAB9AGRM7TSHRCYP3A4
SCHEMBL15768409 0.75 IDO1 (0.40) MAPTSLC6A9SLC6A5IDO1TDO2
SCHEMBL8580097 0.74 TDP1 (0.48) IDO1TDO2SLC6A2SLC6A3HPGD
SCHEMBL7525253 0.73 ALOX5 (0.41) MAPTALOX15ALDH1A1ALOX5
SCHEMBL4611571 0.73 ALDH1A1 (0.47) SLC6A9SLC6A5CYP3A4HPGDALDH1A1
SCHEMBL9834149 0.73 ATM (0.58) TSHRCYP3A4ALDH1A1LMNA
SCHEMBL7607746 0.73 HPGD (0.35) MAPTHPGD
SCHEMBL5053130 0.71 TACR3 (0.34) MAPTSLC6A9SLC6A5IDO1TDO2
SCHEMBL2709731 0.71 ATM (0.41) MAPTIDO1TDO2TSHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981848-A2 11-BETA HSD1 INHIBITORS Wyeth (US) 2008-10-22 EP disclosed
EP-0923544-B1 METHOD FOR THE SYNTHESIS OF AMINES AND AMINO ACIDS WITH ORGANOBORON DERIVATIVES UNIV SOUTHERN CALIFORNIA (US) 2008-10-15 EP disclosed
WO-2007092435-A2 11-BETA HSD1 INHIBITORS WYETH (US) 2007-08-16 WO disclosed
US-6232467-B1 BIOSYNTHESIS OF AN AMINE WITH KETONE AND BORON COMPOUND; COMPOUNDLIBRARIES UNIVERSITY OF SOUTHERN CALIFORNIA 2001-05-15 US disclosed