Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Fluorescein. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 8/20 | 0.87 |
| ▸ | MAPT | P10636 | 4/20 | 0.87 |
| ▸ | MEN1 | O00255 | 4/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.87 |
| ▸ | HTT | P42858 | 2/20 | 0.87 |
| ▸ | HPGD | P15428 | 2/20 | 0.87 |
| ▸ | RECQL | P46063 | 2/20 | 0.87 |
| ▸ | BLM | P54132 | 2/20 | 0.87 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.87 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.87 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.87 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescein SCHEMBL991336 | 0.99 | FTO (0.89) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL11135740 | 0.99 | FTO (0.89) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL106710 | 0.99 | FTO (0.89) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL538249 | 0.95 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL8144835 | 0.95 | FTO (0.97) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL20740618 | 0.94 | FTO (0.85) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL6691088 | 0.93 | FTO (0.94) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL16533 | 0.93 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL30272223 | 0.93 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 | |
| Fluorescein SCHEMBL29371199 | 0.93 | FTO (1.00) | FTOMAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1920257-A1 | OPTICALLY FLUORESCENT NANOPARTICLES | Bayer Schering Pharma AG (DE) | 2008-05-14 | — | — | EP | disclosed |
| US-20070104649-A1 | Optically fluorescent nanoparticles | SCHERING AG (DE) | 2007-05-10 | — | — | US | disclosed |
| WO-2007025768-A1 | OPTICALLY FLUORESCENT NANOPARTICLES | BAYER SCHERING PHARMA AG (DE) | 2007-03-08 | — | — | WO | disclosed |
| EP-1760467-A1 | Optically fluorescent nanoparticles | Schering AG (DE) | 2007-03-07 | — | — | EP | disclosed |
| EP-0948639-B1 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | COULTER INT CORP (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-0948639-A4 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | COULTER INT CORP (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0948639-A1 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | Coulter International Corp. (US) | 1999-10-13 | — | — | EP | disclosed |
| US-5905031-A | Identification of blast cells in a leukocyte cell preparation | COULTER INTERNATIONAL CORP. (US) | 1999-05-18 | — | — | US | disclosed |
| WO-1998020154-A1 | IDENTIFICATION OF BLAST CELLS IN A LEUKOCYTE CELL PREPARATION | COULTER INTERNATIONAL CORP. (US) | 1998-05-14 | — | — | WO | disclosed |