SCHEMBL4630373

SCHEMBL4630373

NC(=O)c1ccc(Oc2ccccc2OC=O)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 14/20 0.62
PARP15 Q460N3 4/20 0.56
PARP14 Q460N5 2/20 0.56
PARP4 Q9UKK3 2/20 0.56
ALDH1A1 P00352 2/20 0.56
KMT2A Q03164 2/20 0.56
PARP16 Q8N5Y8 1/20 0.56
PARP11 Q9NR21 1/20 0.56
PARP3 Q9Y6F1 1/20 0.54
PARP2 Q9UGN5 3/20 0.49
TNKS O95271 1/20 0.49
TNKS2 Q9H2K2 1/20 0.49
CTNNB1 P35222 1/20 0.47
OPRM1 P35372 1/20 0.45
OPRD1 P41143 1/20 0.45
OPRK1 P41145 1/20 0.45
PARP1 P09874 2/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11498069 0.88 PARP10 (0.77) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL23463916 0.81 ALDH1A1 (0.68) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL2560996 0.81 LMNA (0.64) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL25142213 0.80 PARP10 (0.66) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL9633891 0.79 PARP10 (0.61) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL8356494 0.79 LMNA (0.59) ALDH1A1KMT2ACTNNB1L3MBTL1MAPK1
SCHEMBL6630817 0.78 PARP10 (0.68) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL3022362 0.77 PARP10 (1.00) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL11602631 0.77 PARP10 (0.66) PARP10PARP15PARP14PARP4ALDH1A1
SCHEMBL30289632 0.77 PARP10 (1.00) PARP10PARP15PARP14PARP4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1919875-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS Astex Therapeutics Limited (GB) 2008-05-14 EP claimed
WO-2006136829-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS ASTEX THERAPEUTICS LIMITED (GB) 2006-12-28 WO claimed
EP-1919875-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS Astex Therapeutics Limited (GB) 2008-05-14 EP disclosed
WO-2006136829-A2 PYRAZOLE DERIVATIVES AND THEIR USE AS PKA AND PKB MODULATORS ASTEX THERAPEUTICS LIMITED (GB) 2006-12-28 WO disclosed