Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.36 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.34 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.34 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630955 | 0.85 | CHRNB2 (0.35) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL3889279 | 0.75 | TSHR (0.37) | FAAHGAAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL603100 | 0.75 | — | — | |
| SCHEMBL7786235 | 0.75 | KMT2A (0.38) | CHRNB2CHRNA3CHRNA4GNAI3GNAO1 | |
| Hydrochloric Acid SCHEMBL27699750 | 0.74 | TSHR (0.36) | FAAHGAAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL2645151 | 0.73 | L3MBTL1 (0.42) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL6961571 | 0.72 | — | — | |
| SCHEMBL2646658 | 0.72 | L3MBTL1 (0.46) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL10514 | 0.71 | GNAI3 (0.50) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL3891537 | 0.70 | CHRNB2 (0.35) | CHRNB2CHRNA3CHRNA4L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |
| EP-0823420-B1 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| US-5866609-A | PROPHYLACTIC AND THERAPEUTIC AGENTS FOR ARTERIOSCLEROSIS. | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-02-02 | — | — | US | disclosed |
| EP-0823420-A2 | Substituted vinylurea derivatives and their use as ACAT inhibitors | SS PHARMACEUTICAL CO., LTD. (JP) | 1998-02-11 | — | — | EP | disclosed |