Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630962 | 0.82 | IKBKB (0.39) | MEN1KMT2AMAPTLMNAIKBKB | |
| SCHEMBL28712359 | 0.82 | PIK3CA (0.46) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL21373454 | 0.76 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL4530760 | 0.71 | PIK3CA (0.48) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL2369694 | 0.68 | PIK3CA (0.57) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL4526945 | 0.68 | ROCK1 (0.57) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL7831016 | 0.68 | LTB4R (0.47) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL5470733 | 0.68 | MEN1 (0.56) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL3133778 | 0.67 | SCN4A (0.55) | PIK3CAPIK3CBPIK3CGMEN1KMT2A | |
| SCHEMBL31396449 | 0.65 | PIK3CA (0.45) | PIK3CAPIK3CBPIK3CGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |