Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PPID | Q08752 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CASR | P41180 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21753692 | 0.85 | EPHX1 (0.52) | HTTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL15140688 | 0.79 | PORCN (0.64) | ROCK2ROCK1HTTLMNAPOLB | |
| SCHEMBL10458464 | 0.79 | POLB (0.50) | POLBSMN1; SMN2 | |
| SCHEMBL4525925 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1HTTNAMPT | |
| SCHEMBL10458465 | 0.76 | KMT2A (0.49) | HTTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL27744449 | 0.75 | MAPK1 (0.58) | ROCK2ROCK1TAAR1NAMPTLMNA | |
| SCHEMBL27723730 | 0.75 | MAPK1 (0.58) | ROCK2ROCK1TAAR1NAMPTLMNA | |
| SCHEMBL10458695 | 0.75 | MAPT (0.44) | HTTTAAR1NAMPTLMNAPOLB | |
| SCHEMBL10458697 | 0.75 | MAPT (0.44) | HTTTAAR1NAMPTLMNAPOLB | |
| SCHEMBL15140925 | 0.75 | ROCK2 (1.00) | ROCK2ROCK1HTTNAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |