Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.70 |
| ▸ | F12 | P00748 | 3/20 | 0.63 |
| ▸ | MGAM | O43451 | 3/20 | 0.63 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | SI | P14410 | 3/20 | 0.63 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.63 |
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL463198 | 1.00 | MAPT (0.70) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL462691 | 0.87 | NPSR1 (0.60) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL462692 | 0.87 | NPSR1 (0.60) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL461244 | 0.85 | MAPT (0.74) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL461243 | 0.85 | MAPT (0.74) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL15053261 | 0.82 | JUN (0.54) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL15053260 | 0.82 | JUN (0.54) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL8780369 | 0.82 | GAA (0.63) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL8780370 | 0.82 | GAA (0.63) | MAPTNPSR1F12MGAMAMY1A | |
| SCHEMBL15052681 | 0.82 | MAPT (0.60) | MAPTNPSR1F12MGAMAMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853276-B2 | Guanidine derivatives in cinnamic series | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2014-10-07 | — | — | US | disclosed |
| EP-2614046-B1 | NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES | PROD CHIM AUXILIAIRES ET DE SYNTHESE (FR) | 2014-08-20 | — | — | EP | disclosed |
| EP-2614046-A1 | NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES | Produits Chimiques Auxiliaires et de Synthese (FR) | 2013-07-17 | — | — | EP | disclosed |
| US-20130165507-A1 | NEW GUANIDINE DERIVATIVES IN CINNAMIC SERIES | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2013-06-27 | — | — | US | disclosed |
| WO-2012032257-A1 | NOVEL GUANIDINE DERIVATIVES IN THE CINNAMIC SERIES | PRODUITS CHIMIQUES AUXILIAIRES ET DE SYNTHESE (FR) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130165507-A1 | NEW GUANIDINE DERIVATIVES IN CINNAMIC SERIES | GMPS, UNG, AGER | MAPT 2457/4885NPSR1 4424/4885F12 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.