Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | ECE1 | P42892 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383221 | 0.84 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL18065023 | 0.82 | RAB9A (0.42) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL31078958 | 0.81 | DPP4 (0.42) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL3391192 | 0.80 | CYP3A4 (0.42) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL26906223 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL184778 | 0.75 | LMNA (0.61) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL20589075 | 0.75 | POLB (0.49) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL30218180 | 0.75 | GBA2 (0.36) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL25348025 | 0.74 | GBA2 (0.47) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL15715693 | 0.74 | GBA2 (0.47) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |