Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.46 |
| ▸ | NPC1 | O15118 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633594 | 0.85 | FGFR1 (0.48) | RAB9ANPC1HTT | |
| SCHEMBL4632643 | 0.85 | ADORA3 (0.47) | RAB9ANPC1SMN1; SMN2RXFP1MEN1 | |
| SCHEMBL4631861 | 0.84 | RAB9A (0.48) | RAB9ANPC1SMN1; SMN2RXFP1MEN1 | |
| SCHEMBL4632650 | 0.82 | HDAC6 (0.42) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2420086 | 0.81 | NPC1 (0.50) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4631794 | 0.81 | AURKA (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4633224 | 0.81 | CA1 (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3870804 | 0.81 | NPC1 (0.45) | RAB9ANPC1SMN1; SMN2RXFP1MEN1 | |
| SCHEMBL2416163 | 0.80 | TP53 (0.43) | RAB9ANPC1SMN1; SMN2RXFP1MEN1 | |
| SCHEMBL4633621 | 0.79 | MAPK1 (0.46) | RAB9ANPC1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |