Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632642 | 0.86 | ADORA3 (0.48) | ADORA3ADORA2AADORA1NPC1CDC7 | |
| SCHEMBL4632550 | 0.85 | RAB9A (0.46) | NPC1RAB9AKMT2ARXFP1L3MBTL1 | |
| SCHEMBL2411496 | 0.83 | KCNK3 (0.52) | ADORA3ADORA2AADORA1NPC1CDC7 | |
| SCHEMBL4633594 | 0.83 | FGFR1 (0.48) | ADORA3NPC1MAP4K4CDK2GSK3B | |
| SCHEMBL3876663 | 0.82 | GAA (0.53) | ADORA3ADORA2AADORA1NPC1CDC7 | |
| SCHEMBL2415616 | 0.81 | L3MBTL1 (0.46) | ADORA3ADORA2AADORA1NPC1CDC7 | |
| SCHEMBL4632622 | 0.81 | HDAC6 (0.53) | ADORA3NPC1CDK2RAB9AKCNK9 | |
| SCHEMBL2416143 | 0.81 | NPC1 (0.43) | ADORA3ADORA2AADORA1NPC1CDC7 | |
| SCHEMBL2416490 | 0.81 | CDC7 (0.45) | ADORA3ADORA2AADORA1NPC1CDC7 | |
| SCHEMBL4633322 | 0.80 | SMN1; SMN2 (0.53) | NPC1CDC7MAP4K4CDK2HIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |