Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29487677 | 0.88 | CYP1A2 (0.47) | KMOCYP1A2ELANENPC1ALDH1A1 | |
| SCHEMBL47226 | 0.88 | CYP1A2 (0.47) | KMOCYP1A2ELANENPC1ALDH1A1 | |
| Fluoride SCHEMBL31655450 | 0.86 | CYP1A2 (0.46) | KMOCYP1A2ELANENPC1ALDH1A1 | |
| Formic Acid SCHEMBL27515529 | 0.84 | KMO (0.45) | KMOCYP1A2ELANENPC1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL31197687 | 0.80 | KMO (0.49) | KMOELANENPC1ALDH1A1MAPT | |
| SCHEMBL29487791 | 0.77 | TRPA1 (0.42) | KMOCYP1A2NPC1ALDH1A1MAPT | |
| SCHEMBL28449338 | 0.75 | RECQL (0.41) | KMOCYP1A2TRPA1RECQLCDK8 | |
| SCHEMBL31097138 | 0.75 | RECQL (0.43) | KMOCYP1A2ELANEALDH1A1MAPT | |
| Quinoline SCHEMBL27698764 | 0.74 | ALDH1A1 (0.57) | KMOCYP1A2NPC1ALDH1A1RAB9A | |
| SCHEMBL29487819 | 0.73 | TRPA1 (0.39) | KMOCYP1A2NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613781-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |