Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.38 |
| ▸ | TCF7L2 | Q9NQB0 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 3/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436119 | 0.87 | ABL1 (0.43) | HDAC1PRKD1CTNNB1TCF7L2FLT3 | |
| SCHEMBL3107639 | 0.87 | HDAC1 (0.45) | HDAC1PRKD1CTNNB1TCF7L2PARP1 | |
| SCHEMBL2434523 | 0.85 | ABL1 (0.43) | HDAC1PRKD1CTNNB1TCF7L2FLT3 | |
| SCHEMBL3101901 | 0.85 | HDAC1 (0.47) | HDAC1PRKD1CTNNB1TCF7L2PARP1 | |
| SCHEMBL2434540 | 0.83 | ABL1 (0.42) | HDAC1PRKD1CTNNB1TCF7L2FLT3 | |
| SCHEMBL3092925 | 0.83 | HDAC1 (0.45) | HDAC1PRKD1CTNNB1TCF7L2FLT3 | |
| SCHEMBL4632682 | 0.82 | HDAC6 (0.38) | HDAC1FLT3KIT | |
| SCHEMBL4632670 | 0.82 | FLT3 (0.51) | HDAC1CTNNB1TCF7L2FLT3KIT | |
| SCHEMBL4632616 | 0.81 | KDR (0.46) | HDAC1FLT3KIT | |
| SCHEMBL4633324 | 0.81 | ABL1 (0.47) | HDAC1FLT3KITAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |