Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 8/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632622 | 0.88 | HDAC6 (0.53) | SMN1; SMN2NPC1RAB9AHDAC6CDK2 | |
| SCHEMBL4633594 | 0.87 | FGFR1 (0.48) | NPC1RAB9AHDAC6CDK2JAK2 | |
| SCHEMBL4632762 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AHDAC6CDK2 | |
| SCHEMBL4631794 | 0.85 | AURKA (0.46) | SMN1; SMN2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL2413051 | 0.82 | RXFP1 (0.57) | SMN1; SMN2NPC1RAB9AKCNK3KCNK9 | |
| SCHEMBL4632668 | 0.81 | CDK7 (0.50) | SMN1; SMN2NPC1RAB9ACDK2ROCK2 | |
| SCHEMBL4631749 | 0.80 | CDK2 (0.49) | SMN1; SMN2HDAC6CDK2JAK2MAP4K4 | |
| SCHEMBL4632643 | 0.80 | ADORA3 (0.47) | SMN1; SMN2NPC1RAB9ACDK2CDC7 | |
| SCHEMBL2415951 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AHDAC6CDK2 | |
| SCHEMBL4632650 | 0.79 | HDAC6 (0.42) | SMN1; SMN2NPC1RAB9AHDAC6CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |