Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 7/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Albuterol SCHEMBL4632758 | 0.85 | ADRB2 (0.64) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL6838978 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL12158793 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL11289635 | 0.79 | ADRB2 (0.59) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL14141543 | 0.76 | ADRB2 (0.62) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL11287951 | 0.76 | ADRB2 (0.52) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL11286698 | 0.75 | ADRB2 (0.55) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL11329853 | 0.75 | PTGS2 (0.54) | CYP1A2TSHRTDP1 | |
| SCHEMBL4339029 | 0.74 | HTT (0.50) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL11277356 | 0.74 | ADRB2 (0.48) | ADRB2ADRB1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1494711-A4 | METHODS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | ABGENIX INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1494711-A1 | METHODS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | Abgenix, Inc. (US) | 2005-01-12 | — | — | EP | disclosed |
| WO-2003080117-A1 | METHODS FOR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) | ABGENIX, INC. (US) | 2003-10-02 | — | — | WO | disclosed |