Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 9/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632688 | 0.89 | AURKA (0.51) | KITFLT3AURKAFGFR1KDR | |
| SCHEMBL4632686 | 0.87 | AURKA (0.47) | KITFLT3AURKAFGFR1KDR | |
| SCHEMBL4633594 | 0.80 | FGFR1 (0.48) | FLT3AURKAFGFR1 | |
| SCHEMBL4632583 | 0.80 | NTRK1 (0.47) | KITFLT3AURKAFGFR1KDR | |
| SCHEMBL4632650 | 0.80 | HDAC6 (0.42) | FLT3FGFR1NTRK1KDM4EALDH1A1 | |
| SCHEMBL742913 | 0.79 | AURKA (0.65) | KITFLT3AURKA | |
| SCHEMBL4631749 | 0.78 | CDK2 (0.49) | FGFR1 | |
| SCHEMBL4632616 | 0.78 | KDR (0.46) | KITFLT3KDRKDM4EALDH1A1 | |
| SCHEMBL4633324 | 0.78 | ABL1 (0.47) | KITFLT3AURKAKDRKDM4E | |
| SCHEMBL4632622 | 0.78 | HDAC6 (0.53) | FLT3AURKAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |