Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.41 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664696 | 0.81 | CA12 (0.51) | RAB9ANPC1ESR1SMN1; SMN2NPSR1 | |
| SCHEMBL4633246 | 0.80 | LMNA (0.42) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL4634178 | 0.80 | CA12 (0.43) | MAPTALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL6815909 | 0.75 | KMT2A (0.59) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL24985909 | 0.75 | LMNA (0.49) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL4633291 | 0.75 | KMT2A (0.48) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL5924443 | 0.74 | ESR1 (0.69) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL4664889 | 0.73 | LMNA (0.40) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL4737793 | 0.73 | KDM4E (0.41) | KMT2AMAPTALDH1A1RAB9ANPC1 | |
| SCHEMBL2655338 | 0.73 | KMT2A (0.57) | KMT2AMAPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926714-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | Nycomed GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007023135-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2007-03-01 | — | — | WO | disclosed |