Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1454571 | 0.82 | MTNR1A (0.47) | MTNR1AMTNR1BCYP2C19LMNACHRNB4 | |
| SCHEMBL18889915 | 0.81 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2SLC6A4 | |
| SCHEMBL8733440 | 0.80 | MTNR1A (0.50) | MTNR1AMTNR1BCYP2C19LMNACHRNB4 | |
| SCHEMBL11516903 | 0.80 | MTNR1A (0.46) | MTNR1AMTNR1BCYP2C19LMNACHRNB4 | |
| SCHEMBL1778182 | 0.79 | CYP2C19 (0.41) | MTNR1AMTNR1BCYP2C19LTA4HPOLB | |
| SCHEMBL2853850 | 0.78 | MTNR1A (0.45) | MTNR1AMTNR1BLMNACHRNB4CHRNA3 | |
| SCHEMBL27435937 | 0.78 | APP (0.38) | MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL10449438 | 0.78 | LMNA (0.42) | MTNR1AMTNR1BCYP2C19LMNAPOLB | |
| SCHEMBL4711438 | 0.78 | CYP2C19 (0.40) | MTNR1AMTNR1BCYP2C19LTA4HALDH1A1 | |
| SCHEMBL27526890 | 0.77 | MTNR1A (0.44) | MTNR1AMTNR1BLMNACHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022137240-A1 | METHACRYLAMIDES PROTEIN BINDERS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2022-06-30 | — | — | WO | disclosed |
| US-10301297-B2 | Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease | GUANGZHOU INNOCARE PHARMA TECH CO., LTD. (CN) | 2019-05-28 | — | — | US | disclosed |
| US-20180222897-A1 | SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK AND THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASE | GUANGZHOU INNOCARE PHARMA TECH CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-2307025-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS LLC (US) | 2017-09-20 | — | — | EP | disclosed |
| US-20170246169-A1 | Inhibitors of Bruton's Tyrosine Kinase for the Treatment of Solid Tumors | PHARMACYCLICS, INC. | 2017-08-31 | — | — | US | disclosed |
| EP-3204360-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| EP-1530080-B1 | Silver halide color photographic light-sensitive material | FUJIFILM CORP (JP) | 2008-10-29 | — | — | EP | disclosed |
| US-7241563-B2 | Silver halide color photographic light-sensitive material | FUJIFILM CORPORATION (JP) | 2007-07-10 | — | — | US | disclosed |
| US-20050100835-A1 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. | 2005-05-12 | — | — | US | disclosed |
| EP-1530080-A1 | Silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 2005-05-11 | — | — | EP | disclosed |
| WO-1991005750-A2 | PROCESS FOR PRODUCING FLUORINATED ORGANIC COMPOUNDS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-05-02 | — | — | WO | disclosed |
| US-4361573-A | α,α-Diaryl-β-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them | TEMMLER AG (CH) | 1982-11-30 | — | — | US | disclosed |
| US-4025633-A | DIURETICS, SALURETICS | FIRMA TEMMLER A.G. (CH) | 1977-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222897-A1 | SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK AND THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASE | BTK, SYK, LYN | MTNR1A 4174/4885MTNR1B 3598/4885CYP2C19 1466/4885 |
| US-10301297-B2 | Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease | BTK, SYK, LYN | MTNR1A 4174/4885MTNR1B 3598/4885CYP2C19 1466/4885 |
| US-20170246169-A1 | Inhibitors of Bruton's Tyrosine Kinase for the Treatment of Solid Tumors | BTK, ABL1, LYN | MTNR1A 4833/4885MTNR1B 4774/4885CYP2C19 3317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.