Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.38 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635288 | 0.88 | ALDH1A1 (0.37) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL18825589 | 0.82 | CAMK2A (0.36) | KMT2ACA12MMP2CA14 | |
| SCHEMBL18848787 | 0.80 | MEN1 (0.50) | KMT2ADNM1FDPSMMP2 | |
| SCHEMBL18825533 | 0.80 | FAAH (0.34) | KMT2AALDH1A1CA12MMP2CA14 | |
| SCHEMBL22590166 | 0.79 | CTSC (0.41) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL18825598 | 0.78 | GAA (0.41) | HDAC3KMT2AHDAC1HDAC2HDAC8 | |
| SCHEMBL5273087 | 0.75 | CYP1A2 (0.41) | CYP3A4CYP1A2KMT2ADNM1FOLH1 | |
| SCHEMBL3109246 | 0.73 | LMNA (0.43) | LMNABLMCYP3A4NFKB1PMP22 | |
| SCHEMBL18825526 | 0.73 | PLA2G2C (0.30) | CA12MMP2CA14 | |
| SCHEMBL13295944 | 0.72 | KMT2A (0.61) | LMNABLMGABBR2CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079260-A1 | PHOSPHONATE-CHLOROQUINE CONJUGATES AND METHODS USING SAME | UNIVERSITY OF ROCHESTER (US) | 2017-05-11 | — | — | WO | disclosed |
| EP-1928890-B1 | PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS INC (CA) | 2013-04-03 | — | — | EP | disclosed |
| US-8404664-B2 | Phosphonated Rifamycins and uses thereof for the prevention and treatment of bone and joint infections | TARGANTA THERAPEUTICS, INC. (CA) | 2013-03-26 | — | — | US | disclosed |
| EP-1928890-A2 | PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | Targanta Therapeutics Inc. (CA) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007096703-A2 | PHOSPHONATED RIFAMYCINS AND USES THEREOF FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS | TARGANTA THERAPEUTICS INC. (CA) | 2007-08-30 | — | — | WO | disclosed |