Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SENP5 | Q96HI0 | 9/20 | 0.41 |
| ▸ | SENP2 | Q9HC62 | 9/20 | 0.41 |
| ▸ | SENP1 | Q9P0U3 | 9/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4603283 | 0.90 | HSD11B1 (0.44) | HSD11B1ALDH1A1SENP5SENP2SENP1 | |
| SCHEMBL1382902 | 0.87 | LMNA (0.55) | HSD11B1ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL4633589 | 0.82 | ALDH1A1 (0.44) | HSD11B1ALDH1A1SENP5SENP2SENP1 | |
| SCHEMBL4603394 | 0.81 | PTPN1 (0.37) | HSD11B1PTPN1SENP5SENP2SENP1 | |
| SCHEMBL4633019 | 0.78 | PTPN2 (0.48) | PTPN2PTPN1ALDH1A1KDM4ESENP5 | |
| SCHEMBL4634951 | 0.77 | KDM4E (0.67) | PTPN2PTPN1ALDH1A1KDM4ESENP5 | |
| SCHEMBL4827473 | 0.76 | NPC1 (0.33) | HSD11B1ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4632956 | 0.76 | FFAR1 (0.46) | PTPN2PTPN1ALDH1A1KDM4ESENP5 | |
| SCHEMBL4635097 | 0.76 | PTPN2 (0.46) | PTPN2PTPN1ALDH1A1KDM4ESENP5 | |
| SCHEMBL11844857 | 0.73 | PTPN1 (0.76) | PTPN2PTPN1ALDH1A1KDM4EMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |