Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | BCL2 | P10415 | 2/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.35 |
| ▸ | BAD | Q92934 | 2/20 | 0.35 |
| ▸ | F9 | P00740 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633550 | 0.87 | LMNA (0.55) | HSD11B1KMT2AALDH1A1LMNANOD2 | |
| SCHEMBL4603287 | 0.76 | HSD11B1 (0.33) | HSD11B1ALDH1A1 | |
| SCHEMBL2214437 | 0.73 | EDNRA (0.62) | PTPN2PTPN1MCL1EDNRAKMT2A | |
| SCHEMBL4633967 | 0.72 | HSD11B1 (0.46) | HSD11B1PTPN2PTPN1MCL1EDNRA | |
| SCHEMBL1098130 | 0.68 | MCL1 (0.57) | PTPN2PTPN1MCL1EDNRAKMT2A | |
| SCHEMBL4632959 | 0.68 | EDNRA (0.47) | PTPN2PTPN1MCL1EDNRAKMT2A | |
| SCHEMBL24503498 | 0.67 | PABPC1 (0.48) | HSD11B1KMT2AALDH1A1LMNA | |
| SCHEMBL11844857 | 0.67 | PTPN1 (0.76) | PTPN2PTPN1MCL1KMT2AALDH1A1 | |
| SCHEMBL24506357 | 0.67 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL15697532 | 0.67 | PTPN2 (0.56) | PTPN2PTPN1MCL1EDNRAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |