Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
| ▸ | GPR183 | P32249 | 1/20 | 0.33 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3705445 | 0.97 | MEN1 (0.71) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL11294111 | 0.93 | MEN1 (0.67) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL21632603 | 0.90 | MEN1 (0.62) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL4634064 | 0.88 | MEN1 (0.59) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL571834 | 0.86 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL1019777 | 0.86 | MEN1 (0.77) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL6427079 | 0.86 | — | — | |
| Tromethamine SCHEMBL6535708 | 0.84 | MEN1 (0.62) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL7193959 | 0.82 | MEN1 (0.83) | MEN1LMNAKMT2ATNNC1S1PR1 | |
| Tromethamine SCHEMBL11881550 | 0.82 | MEN1 (0.83) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928825-A1 | NOVEL CROSS-LINKERS FOR OBTAINING STRUCTURE INFORMATION ON MOLECULE COMPLEXES | Universiteit van Amsterdam (NL) | 2008-06-11 | — | — | EP | claimed |
| WO-2007035080-A1 | NOVEL CROSS-LINKERS FOR OBTAINING STRUCTURE INFORMATION ON MOLECULE COMPLEXES | UNIVERSITEIT VAN AMSTERDAM (NL) | 2007-03-29 | — | — | WO | claimed |
| WO-2006079364-A1 | SPECIFIC AND MILD PEPTIDE OR AMIDE BOND CLEAVAGE | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2006-08-03 | — | — | WO | claimed |
| EP-1928825-A1 | NOVEL CROSS-LINKERS FOR OBTAINING STRUCTURE INFORMATION ON MOLECULE COMPLEXES | Universiteit van Amsterdam (NL) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007035080-A1 | NOVEL CROSS-LINKERS FOR OBTAINING STRUCTURE INFORMATION ON MOLECULE COMPLEXES | UNIVERSITEIT VAN AMSTERDAM (NL) | 2007-03-29 | — | — | WO | disclosed |