Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 7/20 | 0.43 |
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL463578 | 1.00 | CHKA (0.43) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL5411261 | 0.74 | ACHE (0.49) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL17632298 | 0.74 | ACHE (0.48) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14211654 | 0.72 | ACHE (0.45) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL25848023 | 0.68 | LMNA (0.47) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL9691766 | 0.68 | CHKA (0.58) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL15140537 | 0.67 | CHKA (0.58) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL8441051 | 0.66 | CHKA (0.56) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| Bromide SCHEMBL5206067 | 0.66 | ALDH1A1 (0.62) | CHKALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL10692064 | 0.66 | CHKA (0.57) | CHKALMNAALDH1A1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |