Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.34 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1360908 | 0.84 | CES2 (0.39) | AGTR1CA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL27308697 | 0.82 | CES2 (0.38) | AGTR1CA1CA2CA12CA9 | |
| SCHEMBL2775058 | 0.81 | CA1 (0.50) | AGTR1KMT2AMEN1MAPTCCR1 | |
| SCHEMBL544703 | 0.79 | AGTR1 (0.45) | AGTR1KMT2AMEN1MAPTCCR1 | |
| SCHEMBL18373564 | 0.77 | CES2 (0.34) | AGTR1KMT2AMEN1CA1CA2 | |
| SCHEMBL3422434 | 0.75 | ALDH1A1 (0.37) | KMT2AMEN1MAPTCA1CA2 | |
| SCHEMBL3140914 | 0.70 | CYP3A4 (0.43) | CA1CA2CA12CA9CA7 | |
| SCHEMBL2775884 | 0.70 | CA1 (0.58) | AGTR1CA1CA2CA12CA9 | |
| SCHEMBL11871290 | 0.70 | FABP3 (0.35) | CA1CA2CA12CA9CA7 | |
| Hydrochloric Acid SCHEMBL28280969 | 0.69 | CA12 (0.38) | CA1CA2CA12CA7CA13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934187-A1 | NOVEL BENZIMIDAZOLE AND BENZOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS C-MET INHIBITORS | Aventis Pharma S.A. (FR) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007036630-A1 | NOVEL BENZIMIDAZOLE AND BENZOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS C-MET INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2007-04-05 | — | — | WO | disclosed |