Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | CNR2 | P34972 | 2/20 | 0.56 |
| ▸ | NAMPT | P43490 | 2/20 | 0.55 |
| ▸ | NSD2 | O96028 | 3/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NPY1R | P25929 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22489905 | 0.85 | PRMT6 (0.48) | SMN1; SMN2LMNACNR2NAMPTNSD2 | |
| SCHEMBL4617728 | 0.81 | LMNA (0.60) | SMN1; SMN2LMNACNR2NAMPTHTT | |
| SCHEMBL30230094 | 0.80 | NSD2 (0.57) | CNR2NSD2ALDH1A1HTTPOLB | |
| SCHEMBL17101697 | 0.80 | NPY1R (0.51) | SMN1; SMN2LMNACNR2NSD2ALDH1A1 | |
| SCHEMBL11174344 | 0.78 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNANAMPTNSD2NR2F2 | |
| SCHEMBL12078262 | 0.77 | NAMPT (0.69) | NAMPTRAB9ANPC1 | |
| SCHEMBL4783275 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNACNR2NAMPTNSD2 | |
| SCHEMBL22489803 | 0.74 | SLC22A12 (0.49) | LMNACNR2ALDH1A1POLBRXFP1 | |
| SCHEMBL4662893 | 0.73 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNANAMPTNR2F2ALDH1A1 | |
| SCHEMBL3692624 | 0.73 | CA12 (0.55) | ALDH1A1SLC22A12MMP7CYP2C9SLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |