Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 2/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17101682 | 0.82 | LMNA (0.51) | NSD2CA12CA9MEN1KMT2A | |
| SCHEMBL17101815 | 0.81 | LMNA (0.43) | NSD2SMN1; SMN2CA12CA9SLC22A12 | |
| SCHEMBL4636700 | 0.80 | SMN1; SMN2 (0.57) | NPY1RNPY5RPOLBRXFP1MMP7 | |
| SCHEMBL17101772 | 0.80 | LMNA (0.52) | POLBCA12CA9ALDH1A1LMNA | |
| SCHEMBL17101701 | 0.80 | NR3C2 (0.48) | POLBHTTSMN1; SMN2CA12CA9 | |
| SCHEMBL30230094 | 0.79 | NSD2 (0.57) | NPY1RNPY5RPOLBRXFP1NSD2 | |
| SCHEMBL5167263 | 0.76 | SMN1; SMN2 (0.56) | NSD2SMN1; SMN2CA12CA9ALDH1A1 | |
| SCHEMBL17101757 | 0.76 | MAPT (0.48) | POLBSMN1; SMN2CA9LMNA | |
| SCHEMBL17101690 | 0.73 | CYP19A1 (0.46) | POLBNSD2HTTSMN1; SMN2CA9 | |
| SCHEMBL5651347 | 0.73 | KEAP1 (0.74) | POLBHTTSMN1; SMN2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015140566-A1 | PYRAZOLO-PYRIMIDINES AS INHIBITORS OF BTK | REDX PHARMA PLC (GB) | 2015-09-24 | — | — | WO | disclosed |