Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4617404 | 0.70 | SFRP1 (0.55) | CA1CA2LSSSFRP1ALDH1A1 | |
| SCHEMBL4637488 | 0.66 | PIK3CA (0.47) | SFRP1 | |
| SCHEMBL161783 | 0.66 | HTR6 (0.61) | MAPTCA1CA2CA12CA9 | |
| SCHEMBL7581277 | 0.66 | CA2 (0.46) | MAPTCA1CA2CA12CA9 | |
| SCHEMBL3161980 | 0.66 | HTR2A (0.71) | HTR2AHTR2CCA1CA2CA12 | |
| SCHEMBL4662879 | 0.64 | MAPT (0.46) | MAPTCA1CA2CA12CA9 | |
| SCHEMBL4618689 | 0.64 | SFRP1 (0.55) | CA1CA2CA12CA9CA4 | |
| SCHEMBL24917161 | 0.63 | HTR6 (0.77) | HTR2AHTR2CMAPTCA1CA2 | |
| SCHEMBL6960019 | 0.63 | MAOB (0.66) | MAPT | |
| SCHEMBL7868677 | 0.63 | LSS (0.74) | MAPTCA1CA2LSSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |